Gejala Sisa Penyintas Covid-19: Literatur Review
Keywords:
COVID-19, kesehatan, kesehatan mental, penyintas COVID-19Abstract
Masih banyak ditemukan keluhan dan gejala sisa pada penyintas COVID-19 baik sesaat setelah dinyatakan sembuh hingga 6 bulan setelahnya. Tujuan dari studi literatur ini adalah untuk memberikan gambaran kondisi kesehatan, gejala sisa dan faktor prediktor yang berhubungan dengan kondisi tersebut pada pasien COVID-19 yang telah dinyatakan sembuh. Tinjauan literatur ini menggunakan tiga database, yaitu Scopus, Proquest dan Science Direct yang menemukan 15 ribu lebih artikel dan difilter sesuai dengan kriteria studi yakni artikel full text hasil penelitian ilmiah yang diterbitkan antara tahun 2020-2021 dengan variabel kesehatan pada penyintas COVID-19 hingga menemukan 17 artikel yang direview. Studi ini menjelasakan gambaran kondisi kesehatan baik segi fisik, mental dan sosial. Gejala sisa yang ditemukan meliputi kecemasan (10,4-42%), depresi (1,3-31%), PTSD (11-35%), kelelahan (25,3-87%), defisit kognitif (2,6-23%), sesak napas (2,6-71%), gangguan mobilitas (18-30%), masalah pemenuhan activity daily living (2-36,8%), insomnia (23,2-40%) dan gangguan memori (6,1-28,9%). Selain memberikan dampak negatif, dampak positif juga dilaporkan seperti adanya perubahan gaya hidup ke arah yang lebih sehat dan peningkatan makna keluarga. Sedangkan gambaran faktor prediktor ditemukannya gejala sisa infeksi COVID-19 adalah karakteristik virus COVID-19, kecepatan arus informasi, pembatasan jarak fisik, imbas dari faktor ekonomi, penyesalan, dan stigmatisasi.References
Ameyaw, E. K., Hagan, J. E., Ahinkorah, B. O., Seidu, A. A., & Schack, T. (2020). Mainstream reintegration of COVID-19 survivors and its implications for mental health care in Africa. The Pan African medical journal, 36, 366. doi:10.11604/pamj.2020.36.366.25115
Brown, L. M. (2019). Skills for psychological recovery during and after disasters to strengthen social support. Innovation in Aging, 3(Suppl 1), S391.
Cai, X., Hu, X., Ekumi, I. O., Wang, J., An, Y., Li, Z., & Yuan, B. (2020). Psychological distress and its correlates among COVID-19 survivors during early convalescence across age groups. The American Journal of Geriatric Psychiatry, 28(10), 1030-1039.
Canady, V. A. (2020). Study finds COVIDâ€19 survivors exhibit MH signs one month after treatment. Mental Health Weekly, 30(32). doi:http://dx.doi.org/10.1002/mhw.32474
Chamberlain, S. R., Grant, J. E., Trender, W., Hellyer, P., & Hampshire, A. (2021). Post-traumatic stress disorder symptoms in COVID-19 survivors: online population survey. BJPsych Open, 7(2). doi:http://dx.doi.org/10.1192/bjo.2021.3
Chen, D., Song, F., Cui, N., Tang, L., Zhang, H., Shao, J., . . . Ye, Z. (2021). The Perceptions and Views of Rural Residents Towards COVID-19 Recovered Patients in China: A Descriptive Qualitative Study. International Journal of General Medicine, 14, 709-720. doi:http://dx.doi.org/10.2147/IJGM.S293368
Dantzer, R. (2018). Neuroimmune interactions: from the brain to the immune system and vice versa. Physiological reviews, 98(1), 477-504.
Dedoncker, J., Vanderhasselt, M.-A., Ottaviani, C., & Slavich, G. M. (2021). Mental health during the COVID-19 pandemic and beyond: The importance of the vagus nerve for biopsychosocial resilience. Neuroscience & Biobehavioral Reviews, 125, 1-10. doi:https://doi.org/10.1016/j.neubiorev.2021.02.010
Ferrucci, R., Dini, M., Groppo, E., Rosci, C., & Reitano, M. R. (2021). Long-Lasting Cognitive Abnormalities after COVID-19. Brain Sciences, 11(2), 235. doi:http://dx.doi.org/10.3390/brainsci11020235
Greco, G. I., Noale, M., Trevisan, C., Zatti, G., Dalla Pozza, M., Lazzarin, M., . . . Bellon, S. (2021). Increase in Frailty in Nursing Home Survivors of Coronavirus Disease 2019: Comparison With Noninfected Residents. Journal of the American Medical Directors Association.
Halpin, S. J., McIvor, C., Whyatt, G., Adams, A., Harvey, O., McLean, L., . . . Sivan, M. (2020). Postâ€discharge symptoms and rehabilitation needs in survivors of COVIDâ€19 infection: a crossâ€sectional evaluation. Journal of Medical Virology. doi:http://dx.doi.org/10.1002/jmv.26368
Hansel, T. C., Nakonezny, P. A., & Rodgers, J. L. (2011). Did Divorces Decline After the Attacks on the World Trade Center? 1. Journal of Applied Social Psychology, 41(7), 1680-1700.
Hori, A., Sawano, T., Ozaki, A., & Tsubokura, M. (2021). Exacerbation of Subthreshold PTSD Symptoms in a Great East Japan Earthquake Survivor in the Context of the COVID-19 Pandemic. Case Reports in Psychiatry, 2021. doi:http://dx.doi.org/10.1155/2021/6699775
Huang, C., Huang, L., Wang, Y., Li, X., Ren, L., Gu, X., . . . Cao, B. (2021). 6-month consequences of COVID-19 in patients discharged from hospital: a cohort study. The Lancet, 397(10270), 220-232. doi:http://dx.doi.org/10.1016/S0140-6736(20)32656-8
Jaworski, B. K., Taylor, K., Ramsey, K. M., Heinz, A., Steinmetz, S., Pagano, I., . . . Owen, J. E. (2021). Exploring Usage of COVID Coach, a Public Mental Health App Designed for the COVID-19 Pandemic: Evaluation of Analytics Data. Journal of medical Internet research, 23(3), e26559.
Kisely, S., Warren, N., McMahon, L., Dalais, C., Henry, I., & Siskind, D. (2020). Occurrence, prevention, and management of the psychological effects of emerging virus outbreaks on healthcare workers: rapid review and meta-analysis. BMJ, 369.
Kong, X., Zheng, K., Tang, M., Kong, F., Zhou, J., Diao, L., . . . Dong, Y. (2020). Prevalence and factors associated with depression and anxiety of hospitalized patients with COVID-19. MedRxiv.
Kozato, N., Mishra, M., & Firdosi, M. (2021). New-onset psychosis due to COVID-19. BMJ Case Reports, 14(4). doi:http://dx.doi.org/10.1136/bcr-2021-242538
Krider, A. E., & Parker, T. W. (2021). COVID-19 tele-mental health: Innovative use in rural behavioral health and criminal justice settings. Journal of Rural Mental Health, 45(2), 86-94. doi:http://dx.doi.org/10.1037/rmh0000153
Lange, K. W. (2021). Coronavirus disease 2019 (COVID-19) and global mental health. Global Health Journal. doi:https://doi.org/10.1016/j.glohj.2021.02.004
Liu, D., Baumeister, R. F., Veilleux, J. C., Chen, C., Liu, W., Yue, Y., & Zhang, S. (2020). Risk factors associated with mental illness in hospital discharged patients infected with COVID-19 in Wuhan, China. Psychiatry Research, 292, 113297.
Lötsch, F., Schnyder, J., Goorhuis, A., & Grobusch, M. P. (2017). Neuropsychological long-term sequelae of Ebola virus disease survivors – A systematic review. Travel Medicine and Infectious Disease, 18, 18-23. doi:https://doi.org/10.1016/j.tmaid.2017.05.001
Mahajan, A., & Mason, G. F. (2021). A sobering addition to the literature on COVID-19 and the brain. Journal of Clinical Investigation, 131(8), 1-2. doi:http://dx.doi.org/10.1172/JCI147B29
Mahalakshmi, A. M., Ray, B., Tuladhar, S., Bhat, A., Paneyala, S., Duraisamy, P., . . . Qoronfleh, M. W. (2021). Does COVIDâ€19 contribute to development of neurological disease? Immunity, Inflammation and Disease, 9(1), 48-58. doi:http://dx.doi.org/10.1002/iid3.387
Mahmoudi, H., Saffari, M., Movahedi, M., Sanaeinasab, H., Hojat, R. J., Pourgholami, M., . . . Pakpour, A. H. (2021). A mediating role for mental health in associations between COVIDâ€19â€related selfâ€stigma, PTSD, quality of life, and insomnia among patients recovered from COVIDâ€19. Brain and Behavior. doi:http://dx.doi.org/10.1002/brb3.2138
Marshall, J. M., Dunstan, D. A., & Bartik, W. (2020). The role of digital mental health resources to treat trauma symptoms in Australia during COVID-19. Psychological Trauma: Theory, Research, Practice, and Policy, 12(S1), S269-S271. doi:http://dx.doi.org/10.1037/tra0000627
Martinez-Martin, N., Dasgupta, I., Carter, A., Chandler, J. A., Kellmeyer, P., Kreitmair, K., . . . Cabrera, L. Y. (2020). Ethics of Digital Mental Health During COVID-19: Crisis and Opportunities. JMIR Mental Health, 7(12). doi:http://dx.doi.org/10.2196/23776
Matschke, J., Lütgehetmann, M., Hagel, C., Sperhake, J. P., Schröder, A. S., Edler, C., . . . Glatzel, M. (2020). Neuropathology of patients with COVID-19 in Germany: a post-mortem case series. The Lancet Neurology, 19(11), 919-929. doi:https://doi.org/10.1016/S1474-4422(20)30308-2
Mazza, M. G., De Lorenzo, R., Conte, C., Poletti, S., Vai, B., Bollettini, I., . . . Rovere-Querini, P. (2020). Anxiety and depression in COVID-19 survivors: Role of inflammatory and clinical predictors. Brain, Behavior, and Immunity, 89, 594-600.
Mazza, M. G., Palladini, M., De Lorenzo, R., Magnaghi, C., Poletti, S., Furlan, R., . . . Benedetti, F. (2021). Persistent psychopathology and neurocognitive impairment in COVID-19 survivors: Effect of inflammatory biomarkers at three-month follow-up. Brain, Behavior, and Immunity. doi:https://doi.org/10.1016/j.bbi.2021.02.021
Moradi, Y., Mollazadeh, F., Karimi, P., Hosseingholipour, K., & Baghaei, R. (2020). Psychological disturbances of survivors throughout COVID-19 crisis: a qualitative study. BMC Psychiatry, 20(1). doi:10.1186/s12888-020-03009-w
Musheyev, B., Borg, L., Janowicz, R., Matarlo, M., Boyle, H., Singh, G., . . . Duong, T. Q. (2021). Functional status of mechanically ventilated COVID-19 survivors at ICU and hospital discharge. Journal of Intensive Care, 9, 1-10. doi:http://dx.doi.org/10.1186/s40560-021-00542-y
Oh, T. K., Park, H. Y., & Song, I. A. (2021). Risk of psychological sequelae among coronavirus diseaseâ€2019 survivors: A nationwide cohort study in South Korea. Depression and Anxiety, 38(2), 247-254.
Park, H. Y., Park, W. B., Lee, S. H., Kim, J. L., Lee, J. J., Lee, H., & Shin, H.-S. (2020). Posttraumatic stress disorder and depression of survivors 12 months after the outbreak of Middle East respiratory syndrome in South Korea. BMC public health, 20, 1-9.
Parker, C., Shalev, D., Hsu, I., Shenoy, A., Cheung, S., Nash, S., . . . Shapiro, P. A. (2020). Depression, Anxiety, and Acute Stress Disorder Among Patients Hospitalized With Coronavirus Disease 2019: A Prospective Cohort Study. Psychosomatics. doi:https://doi.org/10.1016/j.psym.2020.10.001
Ramage, A. E. (2020). Potential for Cognitive Communication Impairment in COVID-19 Survivors: A Call to Action for Speech-Language Pathologists. American Journal of Speech - Language Pathology (Online), 29(4), 1821-1832. doi:http://dx.doi.org/10.1044/2020_AJSLP-20-00147
Rass, V., Beer, R., Schiefecker, A. J., Kofler, M., Lindner, A., Mahlknecht, P., . . . Helbok, R. (2021). Neurological outcome and quality of life three months after COVIDâ€19: a prospective observational cohort study. European Journal of Neurology. doi:http://dx.doi.org/10.1111/ene.14803
Reardon, S. (2015). Ebola’s mental-health wounds linger in Africa. Nature News, 519(7541), 13.
Sahoo, S., Mehra, A., Suri, V., Malhotra, P., Yaddanapudi, L. N., Dutt Puri, G., & Grover, S. (2020). Lived experiences of the corona survivors (patients admitted in COVID wards): A narrative real-life documented summaries of internalized guilt, shame, stigma, anger. Asian Journal of Psychiatry, 53. doi:10.1016/j.ajp.2020.102187
Saltzman, L. Y., Hansel, T. C., & Bordnick, P. S. (2020). Loneliness, isolation, and social support factors in post-COVID-19 mental health. Psychological Trauma: Theory, Research, Practice, and Policy, 12(S1), S55-S57. doi:http://dx.doi.org/10.1037/tra0000703
Saltzman, L. Y., Solomyak, L., & Pat-Horenczyk, R. (2017). Addressing the needs of children and youth in the context of war and terrorism: The technological frontier. Current psychiatry reports, 19(6), 30.
Shabir Ahmad, D., Khurshid, S. Q., Zaid Ahmad, W., Khanam, A., Haq, I., Naveed Nazir, S., . . . Hena, M. (2020). Stigma in coronavirus disease-19 survivors in Kashmir, India: A cross-sectional exploratory study. PLoS One, 15(11). doi:http://dx.doi.org/10.1371/journal.pone.0240152
Shang, Y. F., Liu, T., Yu, J. N., Xu, X. R., Zahid, K. R., Wei, Y. C., . . . Zhou, F. L. (2021). Halfâ€year followâ€up of patients recovering from severe COVIDâ€19: Analysis of symptoms and their risk factors. Journal of Internal Medicine. doi:http://dx.doi.org/10.1111/joim.13284
Shigemura, J., Ursano, R. J., Morganstein, J. C., Kurosawa, M., & Benedek, D. M. (2020). Public responses to the novel 2019 coronavirus (2019â€nCoV) in Japan: Mental health consequences and target populations. Psychiatry and clinical neurosciences, 74(4), 281.
Smith, C. M., Komisar, J. R., Ahmad, M., & Kincaid, B. R. (2020). COVID-19-associated brief psychotic disorder. BMJ Case Reports, 13(8). doi:http://dx.doi.org/10.1136/bcr-2020-236940
Song, E., Zhang, C., Israelow, B., Lu-Culligan, A., Prado, A. V., Skriabine, S., . . . Dai, Y. (2021). Neuroinvasion of SARS-CoV-2 in human and mouse brain. Journal of Experimental Medicine, 218(3), e20202135.
Stavem, K., Ghanima, W., Olsen, M. K., Gilboe, H. M., & Einvik, G. (2021). Persistent symptoms 1.5–6 months after COVID-19 in non-hospitalised subjects: a population-based cohort study. Thorax, 76(4), 405-407. doi:http://dx.doi.org/10.1136/thoraxjnl-2020-216377
Theoharides, T. C., Cholevas, C., Polyzoidis, K., & Politis, A. (2021). Longâ€COVID syndromeâ€associated brain fog and chemofog: Luteolin to the rescue. BioFactors. doi:http://dx.doi.org/10.1002/biof.1726
Tingey, J. L., Bentley, J. A., & Hosey, M. M. (2020). COVID-19: Understanding and mitigating trauma in ICU survivors. Psychological Trauma: Theory, Research, Practice, and Policy, 12(S1), S100-S104. doi:http://dx.doi.org/10.1037/tra0000884
Tolba, M., Marwa Abo, O., Hussein, A., & Saeed, H. (2020). Assessment and Characterization of Postâ€COVIDâ€19 manifestations. International Journal of Clinical Practice. doi:http://dx.doi.org/10.1111/ijcp.13746
Tremblay, M.-E., Madore, C., Bordeleau, M., Tian, L., & Verkhratsky, A. (2020). Neuropathobiology of COVID-19: The Role for Glia. Frontiers in Cellular Neuroscience. doi:http://dx.doi.org/10.3389/fncel.2020.592214
Tsiptsios, D., Ouranidis, A., Mueller, C., Schizas, D., Terniotis, C., Nikolakakis, N., . . . Rizos, E. (2021). COVID-19 and its consequences on mental health (Review). Experimental and Therapeutic Medicine, 21(3). doi:http://dx.doi.org/10.3892/etm.2021.9675
Varatharaj, A., Thomas, N., Ellul, M. A., Davies, N. W., Pollak, T. A., Tenorio, E. L., . . . Zandi, M. (2020). Neurological and neuropsychiatric complications of COVID-19 in 153 patients: a UK-wide surveillance study. The Lancet Psychiatry, 7(10), 875-882.
Wu, C., Cheng, J., Zou, J., Duan, L., & Campbell, J. E. (2021). Health-related quality of life of hospitalized COVID-19 survivors: An initial exploration in Nanning city, China. Social Science & Medicine, 274, 113748.
Xiao, S., Luo, D., & Xiao, Y. (2020). Survivors of COVID-19 are at high risk of posttraumatic stress disorder. Global Health Research and Policy, 5(1). doi:10.1186/s41256-020-00155-2
Yvonne, M. J. G., Maarten Van, H., Delbressine, J. M., Vaes, A. W., Meys, R., Felipe, V. C. M., Spruit, M. A. (2020). Persistent symptoms 3 months after a SARS-CoV-2 infection: the post-COVID-19 syndrome? ERJ Open Research, 6(4). doi:http://dx.doi.org/10.1183/23120541.00542-2020
Zhang, H., Hook, J. N., Hodge, A. S., Coomes, S. P., Davis, C. W., Karwoski, L. T., . . . Aten, J. D. (2020). The Effect of Spiritual Fortitude on Mental Health Symptoms Amidst the COVID-19 Pandemic. Journal of Psychology and Christianity, 39(4), 288-300. Retrieved from https://www.proquest.com/scholarly-journals/effect-spiritual-fortitude-on-mental-health/docview/2509691739/se-2?accountid=17242
Zhu, S., Gao, Q., Yang, L., Yang, Y., Xia, W., Cai, X., Reinhardt, J. D. (2020). Prevalence and risk factors of disability and anxiety in a retrospective cohort of 432 survivors of Coronavirus Disease-2019 (Covid-19) from China. PLoS One, 15(12). doi:http://dx.doi.org/10.1371/journal.pone.0243883
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2021 Jurnal Ilmu Keperawatan Jiwa
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Authors who publish with this journal agree to the following terms:
Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
This work is licensed under a Creative Commons Attribution 4.0 International License.